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Prolotherapy (short for proliferation therapy) is an injection-based treatment used to stimulate the body’s natural healing processes, especially for chronic musculoskeletal pain and joint instability. combination of genetic, environmental, and psychological factors that affect how the brain and spinal cord process pain signals.
A mild irritant solution—usually a dextrose (sugar) mixture—is injected into ligaments, tendons, or joint spaces.
This triggers a localized inflammatory response, which promotes tissue repair and strengthening over time.
It’s commonly used for chronic tendon or ligament injuries, osteoarthritis, and joint laxity.
Low back pain (esp. from ligament laxity)
Knee osteoarthritis
Shoulder instability
Tendinopathies (e.g., tennis elbow)
Sacroiliac joint dysfunction
Minimally invasive
Non-surgical
May reduce pain and improve function
Low risk of serious side effects
Not all insurance plans cover it
Evidence is mixed—more high-quality studies are needed
Multiple sessions are often required
Best results seen in well-selected patients
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